Most computational neuroscientists investigate electric dynamics in neurons or neural networks, but there is also computations going on inside neurons.
Here the key dynamical variables are concentrations of numerous different molecules, and the signaling is typically done in cascades of chemical reactions, called signaling pathways.
Today’s guest is an expert in this kind of modelling and is particularly interested in the signaling role of calcium.
Links:
- J. Jędrzejewska-Szmek, D.B. Dorman, K.T. Blackwell: “Making time and space for calcium control of neuron activity”, Current Opinion in Neurobiology, 2023
- J. Hellgren-Kotaleski, K.T. Blackwell: “Modelling the molecular mechanisms of synaptic plasticity using systems biology approaches”, Nature Reviews Neuroscience, 2023
- Homepage of Avrama Blackwell
The podcast was recorded on April 24th, 2024 and lasts 1 hour and 31 minutes.
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