Neurons need particular sodium and potassium concentration gradients across their membranes to function. These gradients are set up by so-called ion pumps which require energy stored in ATP molecules to run.
ATP is the common energy currency in the brain and is produced from nutrients delivered by the blood by a complicated set of chemical reactions known as a metabolic network.
Today’s guest has just published a comprehensive model of such a network and explains how it can shed light on differences between young and brains.
Links:
- Shichkova et al.: “Breakdown and repair of metabolism in the aging brain”, Frontiers in Science (2025)
- Farina et al.: “A multiscale electro-metabolic model of a rat neocortical circuit reveals the impact of ageing on central cortical layers”, PLoS Computational Biology, (2025)
The podcast was recorded on November 14th, 2025 and lasts 1 hour and 31 minutes.
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