Numerous neuron models have been made, but most of them are “single-purpose” in that they are made to address a single scientific question. In contrast, multipurpose neuron models are made to be used to address many scientific questions.
In 2011, the guest published a multipurpose rodent pyramidal-cell model which has been actively used by the community ever since.
We talk about how such models are made, and how his group later built human neuron models to explore network dynamics in brains of depressed patients.
Links:
- Hay, Hill, Schürmann, Markram, Segev: “Models of Neocortical Layer 5b Pyramidal Cells Capturing a Wide Range of Dendritic and Perisomatic Active Properties”, PLoS Computational Biology (2011)
- Hay, Schürmann, Markram, Segev: “Preserving axosomatic spiking features despite diverse dendritic morphology”, Journal of Neurophysiology (2013)
- Yao et al: “Reduced inhibition in depression impairs stimulus processing in human cortical microcircuits”, Cell Reports (2022)
- Guet-McCreight et al: “Therapeutic dose prediction of α5-GABA receptor modulation from simulated EEG of depression severity”, PLoS Computational Biology (2024)
- Rosanally et al: “Linking reduced prefrontal microcircuit inhibition in schizophrenia to EEG biomarkers in silico”, bioRxiv (2024)
- OpenSourceBrain
- Home page of Etay Hay
The podcast was recorded on March 28th, 2025 and lasts 1 hour and 13 minutes.
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