Historically, the analysis of neural recordings focused on responses of single neurons recorded by single-contact electrodes. Modern electrodes with multiple electrode contacts can instead record spikes (action potentials) from hundreds of neurons simultaneously.
Manifold analysis of the overall population activity of these neurons has become a critical tool for interpretation of such data.
The podcast guest is a pioneer in the development and use of such analysis.
Links:
- Fortunato et al.: “Nonlinear manifolds underlie neural population activity during behaviour”, bioRxiv (2024)
- Jazayeri & Ostojic: “Interpreting neural computations by examining intrinsic and embedding dimensionality of neural activity”, Current Opinion in Neurobiology (2021)
- Gallego et al.: “Neural Manifolds for the Control of Movement”, Neuron (2017)
- Gao et al.: “A theory of multineuronal dimensionality, dynamics and measurement”, bioRxiv (2017)
- Churchland et al.: “Neural population dynamics during reaching”, Nature (2012)
- LeCun et al.: “Optimal brain damage”, NIPS proceedings (1989)
The podcast was recorded on November 17th, 2025 and lasts 2 hours and 4 minutes.
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